Guns are the number 1 cause of death for children and teenagers in the US. Approximately every 40 minutes, a child or teenager is injured by a gun. Children who live in a home with a gun are at 2 times the risk of homicide and 3 times the risk of suicide. Increased gun sales and isolation during the coronavirus disease 2019 (COVID-19) pandemic increase the risk of youth gun-related injuries. Caregivers can prevent gun-related injuries by talking to their children about gun safety and removing guns from the home or safely storing guns if they are present.