Alzheimer’s disease is a prevalent age-related medical problem world-wide for which there is no cure. Over the past few decades, researchers have identified 14 potentially modifiable risk factors for this disease. They include physical inactivity, unhealthy diet, and cardiovascular risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking. It is estimated that a third of Alzheimer’s disease cases can be prevented by addressing risk factors at an earlier age. In addition, available data suggest that some dietary supplements may be helpful in preventing or treating dementia, though further high quality studies are needed.